Doxycycline is an antibiotic used for treating bacterial infections. The drug is also sold under the brand names Oracea, Doryx, Monodox, Periostat, and goodrx doxycycline Vibramycin. Doxycycline is in a class of medications called tetracyclines, and it's a broad-spectrum antibiotic, which means it works against a wide range of bacteria. Doctors prescribe doxycycline to prevent malaria and treat a wide range of infections, including: Doxycycline works by preventing the growth and spread of bacteria. Like all antibiotics, doxycycline will not treat colds, the flu, or other infections caused by viruses or fungi. A 2014 study found that a low dose of 40 milligrams (mg) of slow-release doxycycline daily could be an effective and safe therapy for ocular rosacea, or rosacea that affects the eyes. The drug company Pfizer developed doxycycline in the early 1960s, and the Food and Drug Administration (FDA) approved the drug in 1967 under the brand name Vibramycin. In 1994 the FDA also approved the drug to prevent malaria. Doxycycline for Acne, for many years, doctors have prescribed doxycycline to treat acne. It's sometimes used as an alternative to another acne drug with more side effects, minocycline. However, a study published in 2015 found that people with acne who used an antibiotic-free facial gel had greatly improved acne, according. The study suggests that using the facial gel containing adapalene /benzoyl peroxide might be a better alternative than using antibiotics such as doxycycline for acne. Doxycycline Warnings, there are several important warnings you should know about before taking goodrx doxycycline doxycycline. You should take this medication only to treat bacterial infections, and it's important to take it exactly as your doctor prescribes. Using doxycycline or other antibiotics incorrectly or using them to treat infections caused by other types of germs, such as viruses, contributes to the development of drug-resistant bacteria. Every time you take an antibiotic, it kills the sensitive bacteria. Resistant germs, however, can grow and multiply, and then surviving bacteria can become resistant. It's also important to understand that taking antibiotics, including doxycycline, alters the normal balance of bacteria in your body. In addition to killing harmful bacteria, the medication can also reduce the amount of good bacteria that help keep other germs in check. As a result, some people taking doxycycline develop yeast infections and antibiotic-related diarrhea. Taking doxycycline could make oral birth control pills less effective. If you are on oral contraceptives, you should use other forms of birth control while you take this antibiotic. Before taking doxycycline, let your doctor know if you're going to have any kind of surgery, including dental surgery. Your doctor also needs to know if you've ever had liver or kidney disease. Also tell your doctor if you have diabetes. Taking doxycycline can interfere with tests for sugar in the urine. Talk with your doctor before changing your diet or your diabetes treatment plan. Pregnancy and Doxycycline, pregnant women should not take doxycycline because the drug can be harmful to an unborn baby. Tetracyclines, including doxycycline, also pass into breast milk, so women who are breastfeeding should not take this drug. If you're a woman, let your doctor know if you are pregnant, plan to become pregnant, or are breastfeeding. It's also important to note that unborn babies exposed to doxycycline or children younger than 8 years old who take the drug may have permanently stained teeth. Children younger than 8 should not take doxycycline except as treatment for inhalational anthrax or if a doctor decides it's necessary. Doxycycline for Dogs and Cats, doxycycline is often used to treat bacterial infections in dogs, cats, and other animals. Doxycycline may be prescribed to treat several bacterial infections, such as leptospirosis, urinary tract infections (UTI toxoplasmosis, erlichiosis, or mycoplasma. It's also used to treat tick-borne diseases, including Lyme disease and Rocky Mountain spotted fever.
Doxycycline package insert
Dosage Form: capsule, gelatin coated, show On This Page, view All. Show On This Page, to reduce the development of drug-resistant bacteria doxycycline package insert and maintain the effectiveness of Doxycycline Hyclate capsules and other antibacterial drugs, Doxycycline Hyclate capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused. Doxycycline Hyclate Description, doxycycline Hyclate Capsules, USP, are an antibacterial drug synthetically derived from oxytetracycline. The structural formula of doxycycline monohydrate doxycycline package insert is with a molecular formula of C22H24N2O8H2O and a molecular weight of 462.46. The chemical designation for doxycycline is monohydrate. The molecular formula for doxycycline hydrochloride hemiethanolate doxycycline package insert hemihydrate is (C22H24N2O8HCl)2C2H6OH2O and the molecular weight is 1025.89. Doxycycline is a light yellow crystalline powder. Doxycycline Hyclate is soluble in doxycycline package insert water, while doxycycline monohydrate is very slightly soluble in water. Doxycycline has a high degree of lipoid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. Doxycycline will not degrade into an epianhydro form. Each capsule for oral administration contains Doxycycline Hyclate equivalent to 50 mg or 100 mg of doxycycline (anhydrous). Inactive ingredients: lactose monohydrate, microcrystalline cellulose, magnesium stearate. The 50 mg and 100 mg capsule shells contain: gelatin, diacetylated monoglycerides, sucrose fatty acid esters, glacial acetic acid, sodium lauryl sulfate, colloidal silicon dioxide, FD C Blue #1 and titanium dioxide. The printing ink may contain: Shellac Glaze, Iron Oxide Black, N-Butyl Alcohol, Propylene Glycol, SDA 3A Alcohol, FD C Blue #2, FD C Red #40, FD C Blue #1, D C Yellow #10. Doxycycline Hyclate - Clinical Pharmacology. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral administration. Following a 200 mg dose, normal adult volunteers averaged peak doxycycline package insert serum levels.6 mcg/mL of doxycycline at 2 hours, decreasing.45 mcg/mL at 24 hours. Excretion of doxycycline by the kidney is about 40 per 72 hours in individuals with normal function (creatinine clearance about 75 mL/min). This percentage excretion may fall as low as 1 to 5 per 72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min). Studies have shown no significant difference in serum half-life of doxycycline (range 18 to 22 hours) in individuals with normal and severely impaired renal function. Hemodialysis does not alter serum half-life. Results of animal studies indicate that tetracyclines cross the placenta and are found in fetal tissues. Microbiology, mechanism of Action, doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. Resistance, cross resistance with other tetracyclines is common. Antimicrobial Activity, doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections as described in the. Indications AND usage section of the package insert for Doxycycline Hyclate capsules. Gram-Negative Bacteria, acinetobacter species, bartonella bacilliformis, brucella species. Klebsiella species, klebsiella granulomatis, campylobacter fetus, enterobacter aerogenes. Escherichia coli, francisella tularensis, haemophilus ducreyi, haemophilus influenzae. Neisseria gonorrhoeae, shigella species, vibrio cholerae, yersinia pestis. Gram-Positive Bacteria, bacillus anthracis, listeria monocytogenes, streptococcus pneumoniae. Anaerobic Bacteria, clostridium species, fusobacterium fusiforme, propionibacterium acnes. Other Bacteria Nocardiae and other aerobic Actinomyces species Borrelia recurrentis Chlamydophila psittaci Chlamydia trachomatis Mycoplasma pneumoniae Rickettsiae Treponema pallidum Treponema pallidum subspecies pertenue Ureaplasma urealyticum Parasites Balantidium coli Entamoeba species Plasmodium falciparum* *Doxycycline has been found to be active against the asexual erythrocytic forms. The precise mechanism of action of the drug is not known. Susceptibility Testing Methods When available, the clinical microbiology laboratory should provide cumulative reports of in vitro susceptibility test results for antimicrobial drugs used in local hospitals and practice areas to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. These reports should aid the physician in selecting the most effective antimicrobial. Dilution Techniques Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standardized test method1,2,4 (broth or agar). The MIC values should be interpreted according to criteria provided in Table. Diffusion Techniques Quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. The zone size should be determined using a standardized test method.1,3,4 This procedure uses paper disks impregnated with 30 mcg doxycycline to test the susceptibility of microorganisms to doxycycline.
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