Generic name: levothyroxine sodium 300ug, dosage form: tablet, medically reviewed on February 19, 2018. Administer synthroid as a cytomel dosage with synthroid single daily dose, on an empty stomach, one-half to one hour before breakfast. Administer synthroid at least 4 hours before or after drugs known to interfere with synthroid absorption see Drug Interactions (7.1). Evaluate the need for dose side effects for synthroid adjustments when regularly administering within one hour of brand synthroid certain foods that may affect synthroid absorption see Drug Interactions (7.9) and Clinical Pharmacology (12.3). Administer synthroid to infants and children who cannot swallow intact tablets by crushing the tablet, suspending the freshly crushed tablet in a small amount (5 to 10 mL or 1 to 2 teaspoons) of water and immediately administering the suspension by spoon or dropper. Do not store the suspension. Do not administer in foods that decrease absorption of synthroid, such as soybean-based infant formula see Drug Interactions (7.9). General Principles cytomel dosage with synthroid of Dosing, the dose of synthroid for hypothyroidism or pituitary TSH suppression depends on a variety of factors including: the patient's age, body weight, cardiovascular status, side effects for synthroid concomitant medical conditions (including pregnancy concomitant medications, co-administered food and the specific cytomel dosage with synthroid nature of the condition being. Dosing must be individualized to account for these factors and dose adjustments made based on periodic assessment of the patient's clinical response and laboratory parameters see Dosage and Administration (2.4). The peak therapeutic effect of a given dose of synthroid may not be attained for 4 to 6 weeks. Dosing in Specific Patient Populations, primary Hypothyroidism in Adults and in Adolescents in Whom Growth and Puberty are Complete. Start synthroid at the full synthroid and testosterone interaction synthroid and testosterone interaction replacement dose in otherwise healthy, non-elderly individuals who have been hypothyroid for only a short time (such as a few months). The average full replacement dose of synthroid is approximately.6 mcg per kg per day (for example: 100 to 125 mcg per day for a 70 kg adult). Adjust the dose.5 to 25 mcg increments every 4 to 6 weeks until the patient synthroid and testosterone interaction is clinically euthyroid and the serum TSH returns to normal. Doses greater than 200 mcg per day are seldom required. An inadequate response to daily doses of greater than 300 mcg per day is rare and may indicate poor compliance, malabsorption, drug interactions, or a combination of these factors. For elderly patients or patients with underlying cardiac disease, start with a dose.5 to 25 mcg per day. Increase the dose every 6 to 8 weeks, as needed until the patient is clinically euthyroid and the serum TSH returns to normal. The full replacement dose of synthroid may be less than 1 mcg per kg per day in elderly patients. In patients with severe longstanding cytomel dosage with synthroid hypothyroidism, start with a dose.5 to 25 mcg per day. Adjust the dose.5 to 25 mcg increments every 2 to 4 weeks until the patient is clinically euthyroid and the serum TSH level is normalized. Secondary or Tertiary Hypothyroidism, start synthroid at the full replacement dose in otherwise healthy, non-elderly individuals. Start with a lower dose in elderly patients, patients with underlying cardiovascular disease or patients with severe longstanding hypothyroidism as described above. Serum TSH is not a reliable measure of synthroid dose adequacy in patients with secondary or tertiary hypothyroidism and should not be used to monitor therapy. Use the serum free-T4 level to monitor adequacy of therapy cytomel dosage with synthroid in this patient population. Titrate synthroid dosing per above instructions until the patient is clinically euthyroid and the serum free-T4 level is restored to the upper half of the normal range. Pediatric Dosage - Congenital or Acquired Hypothyroidism. The recommended daily dose of synthroid in pediatric patients with hypothyroidism is based on body weight and changes with age as described in Table. Start synthroid at the full daily dose in most pediatric patients. Start at a lower starting dose in newborns (0-3 months) at risk for cardiac failure and in children at risk for hyperactivity (see below). Monitor for clinical and laboratory response see Dosage and Administration (2.4). Synthroid Dosing Guidelines for Pediatric Hypothyroidism. AGE, daily Dose Per Kg Body Weighta 0-3 months 10-15 mcg/kg/day 3-6 months 8-10 mcg/kg/day 6-12 months 6-8 mcg/kg/day 1-5 years 5-6 mcg/kg/day 6-12 years 4-5 mcg/kg/day Greater than 12 years but growth and puberty incomplete 2-3 mcg/kg/day Growth and puberty complete.6 mcg/kg/day The. Newborns (0-3 months) at risk for cardiac failure: Consider a lower starting dose in newborns at risk for cardiac failure. Increase the dose every 4 to 6 weeks as needed based on clinical and laboratory response. Children at risk for hyperactivity: To minimize the risk of hyperactivity in children, start at one-fourth the recommended full replacement dose, and increase on a weekly basis by one-fourth the full recommended replacement dose until the full recommended replacement dose is reached. Pregnancy Pre-existing Hypothyroidism: synthroid dose requirements may increase during pregnancy. Measure serum TSH and free-T4 as soon as pregnancy is confirmed and, at minimum, during each trimester of pregnancy. In patients with primary hypothyroidism, maintain serum TSH in the trimester-specific reference range. For patients with serum TSH above the normal trimester-specific range, increase the dose of synthroid.5 to 25 mcg/day and measure TSH every 4 weeks until a stable synthroid dose is reached and serum TSH is within the normal trimester-specific range. Reduce synthroid dosage to pre-pregnancy levels immediately after delivery and measure serum TSH levels 4 to 8 weeks postpartum to ensure synthroid dose is appropriate. New Onset Hypothyroidism: Normalize thyroid function as rapidly as possible. In patients with moderate to severe signs and symptoms of hypothyroidism, start synthroid at the full replacement dose (1.6 mcg per kg body weight per day). In patients with mild hypothyroidism (TSH 10 IU per liter) start synthroid.0 mcg per kg body weight per day. Evaluate serum TSH every 4 weeks and adjust synthroid dosage until a serum TSH is within the normal trimester specific range see Use in Specific Populations (8.1). TSH Suppression in Well-differentiated Thyroid Cancer Generally, TSH is suppressed to below.1 IU per liter, and this usually requires a synthroid dose of greater than 2 mcg per kg per day.
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